- Rhizopoda
- Rhode Island
- Rhode, Paul Peter
- Richmond (California)
- Richmond (Indiana)
- Richmond (Kentucky)
- Richmond (Virginia)
- Ridder, Herman
- Ridpath, John Clark
- Riel, Louis
- Rienzi, Nicola Gabrini
- Robin, American
- Robin Goodfellow
- Robin Hood
- Robins, Elizabeth
- Robins, Raymond
- Robinson, Edward
- Robinson, Edwin Arlington
- Rolland, Romain
- Roller
- Rolling mill
- Roosevelt
- Roosevelt, Franklin Delano
- Roosevelt, Kermit
- Roosevelt, Quentin
- Roosevelt, Robert Barnwell
- Roosevelt, Theodore (elder)
- Roosevelt, Theodore (younger)
- Rouget de Lisle, Claude Joseph
- Russell, William Clark
- Russell, William Eustis
- Russell, Sir William Howard
- Russell Sage Foundation
- Russia
- Russia Leather
- Russniaks
- Russo-Japanese War
- Rutgers College
- Ruth
- Rutledge, Edward
- Rutledge, John
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- Sault Sainte Marie (Ontario)
- Sault Sainte Marie (Michigan)
- Sault Sainte Marie Falls
- Savanna (plain)
- Savanna (city)
- Savannah (city)
- Savannah (river)
- Savary, Anne Jean Marie René, Duc de Rovigo
- Save
- Savings Banks
- Scheelite
- Scheff, Fritzi
- Scheffel, Joseph Victor von
- Scheffer, Ary
- Scheldt
- Schiff, Jacob Henry
- Schiller, Johann Christoph Friedrich von
- Schinner, Augustin Francis
- Schlangenbad
- Schlegel, August Wilhelm von
- Schlegel, Friedrich von
- Schleswig (duchy)
- Schleswig (seaport)
- Schnitzer, Edward
- Schnitzler, Arthur
- Schools, Medical inspection of
- Schooner
- Schopenhauer, Arthur
- Schouler, James
- Schreiner, Olive
- Schurz, Carl
- Schuster, Arthur
- Schuster, Sir Felix
- Schütt
- Schwab, Charles M.
- Schwan, Theodore
- Schwartz, Berthold
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- Seattle
- Sel d'Or
- Selective Draft Law
- Selenite
- Selenium
- Seleucia
- Sells, Cato
- Selma
- Seward, William Henry
- Seward, Mount
- Seward Peninsula
- Sheehan, Patrick Augustine
- Sheehan, Perley Poore
- Sherman, Roger
- Shirley, James
- Shreveport
- Sigel, Franz
- Sioux Falls
- Sioux Indians
- Siphon
- Siren
- Sitka
- Slezak, Leo
- Slidell, John
- Sligo
- Sloan, John
- Sloane, William Milligan
- Slocum, Henry Warner
- Smith, Edgar Fahs
- Sophocles
- South Bethlehem
- Southbridge
- South Britain
- South Carolina
- South Carolina, University of
- South Dakota
- South Dakota, University of
- Southend
- Southern Alps
- Southern Baptists
- Southern California, University of
- Southern Cross
- Southey, Robert
- South Georgia
- South Hadley
- Southington
- South Island
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