English: (A) Latency to find the platform of wild-type and Neto1-null mice at each day of training in the Morris water maze task. Mice were administered either vehicle (25% cyclodextran) or 15 mg/kg CX546. During pretraining, escape latency to a visible-cued (V) platform located in the northeast (NE) quadrant was unaffected by genotype (unpublished data). In the acquisition phase (days 1–6), escape latency to find a hidden platform located in the southeast (SE) quadrant was also unaffected by genotype (F1,10 = 0.544, p > 0.05). In the second acquisition phase (days 7–9), Neto1-null mice treated with vehicle had longer escape latencies compared with Neto1-null mice treated with CX546, as well as wild-type mice treated with the vehicle control or CX546 when the hidden platform was relocated to the northwest (NW) quadrant (three-way ANOVA, genotype effect, F1,20 = 8.28, p < 0.01). In contrast, Neto1-null mice treated with CX546 had escape latencies identical to wild-type mice treated with the vehicle or CX546 (one-way ANOVA, F1,15 = 0.45; p = 0.7). There was no difference in escape latency between Neto1-null and wild-type mice treated with CX546 (F1,10 = 0.977, p > 0.05).