travels along a certain definite channel because of the peculiar chemical nature of the cell protoplasm. Once started, the process of katabolism takes a definite course, with formation invariably of the same products, because that particular cell protoplasm, owing to its peculiar make-up, tends to break down along certain definite lines of cleavage, as it were, and so the products split off are always the same.
We already have considerable knowledge which tends to indicate that the cells of individual organs and tissues have a certain individuality as regards their primary components, notably in the nucleoproteids present, but our knowledge is by no means complete enough to permit of broad generalization. The problem is an interesting one, and permits of a definite answer by the application of thorough and persistent investigation.
As an allied question, more or less in harmony with what has just been said, reference may be made to the part which ferments and enzymes possibly play in initiating and carrying forward tissue changes, as well as the metabolic changes that occur in glandular organs. Ferments have come into such prominence of late years as responsible agents for so many transformations, that we may well query whether their influence does not extend far beyond the limits originally assigned to their field of activity. The discovery of oxidases and the part which these agents may play in tissue changes, the undoubted existence of ferments in such glands as the thymus, suprarenal, spleen, etc., by which the recently studied autolytic changes in these glands are produced, raise the question whether ferments or enzymes are not far more largely responsible for the many transformations that take place in active tissues than has been hitherto supposed. Consider for a moment the peculiar products which result from the self-digestion (autolysis) of many of the glands so far studied. Note how the nucleoproteid of the thymus, for example, breaks down, yielding xanthin and a little hypoxanthin, together with uracil, but no guanin, adenin or thymin.[1] How the adrenal nucleoproteid likewise yields by autolysis considerable xanthin, but only traces at the most of the other alloxuric bases (Jones). By the self-digestion of the spleen, guanin as well as hypoxanthin is conspicuous, but it is a noticeable fact that in the autolysis of the thymus, for example, there is no appreciable amount of leucin to be detected, thus indicating that the above autolytic changes are not due to any ordinary proteolytic enzyme, but to some peculiar enzyme which acts directly and solely upon the nucleoproteids, splitting off certain of the contained alloxuric groups. In harmony with this view, Jones has just announced the presence in the pancreas, thymus and adrenals, of an enzyme to which he gives the name of guanase, which has the power of transforming guanin into xanthin. The same
- ↑ Jones, 'Ueber die Selbstverdauung von Nucleoproteiden,' Zeitschrift für physiologische Chemie, Band 42, p. 35.
