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MADISONVILLE. A city and the county-seat of Hopkins County, Ky., 38 miles south of Henderson; on the Louisville and Nashville Railroad (Map: Kentucky, D 3). It is the centre of a fine agricultural country, and has an important tobacco trade and various industrial plants, including saw and planing mills, flour mills, a tobacco factory, tobacco stemmeries, a coal mine, etc. Natural gas has been discovered in the vicinity. Population, in 1890, 2212; in 1900, 3628.