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unwarranted by the evidence on any accepted methods of scientific reasoning, but it is disproved by several important facts. In the first place the decline in the first quarter of the century is a clear continuation of a decline which had been going on during the preceding forty years, and whatever causes produced that earlier decline may very well have produced the continuation of it. Again, in the first quarter of the century, vaccination was comparatively small in amount and imperfectly performed. Since 1854 it has been compulsory and almost universal; yet from 1854 to 1884 there is almost no decline of small-pox perceptible, and the severest epidemic of the century occurred in the midst of that period. Yet again, the one clearly marked decline of small-pox has been in the ten years from 1886 to 1896, and it is precisely in this period that there has been a great falling off in vaccination in London from only 7 per cent, less than the births in 1885 to 20.6 per cent, less in 1894, the last year given in the Reports of the Local Government Board; and the decrease of vaccinations has continued since. But even more important, as showing that vaccination has had nothing whatever to do with the decrease of small-pox, is the very close general parallelism of the line snowing the other zymotic diseases, the diminution of which it is admitted has been caused by improved hygienic conditions. The decline of this group of diseases in the first quarter of this century, though somewhat less regular, is quite as well marked as in the case of small-pox, as is also its decline in the last forty years of the 18th century, strongly suggesting that both declines are due to common causes. Let any one examine this diagram carefully and say if it is credible that from 1760 to 1800 both declines are due to some improved conditions of hygiene and sanitation, but that after 1800, while the zymotics have continued to decline from the same class of causes one zymotic—small-pox—must have been influenced by a new cause—vaccination, to produce its corresponding decline. Yet this is the astounding claim made by