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Plague Conference at Mukden, in April 1911; acting Senior Vice-President of the Board of Foreign Affairs, it August 1911; and was nominated Chinese Minister to America, Peru, Mexico and Cuba just after the outbreak of the First Revolution (October 1911) but he did not proceed. In May 1911 Mr. Sze was appointed Minister of Communications in tang Shao-i's Cabinet. This position he held for less than three months and resigned on account of ill-health. He is related, by marriage, to Tang Shao-i. In December 1913 he was appointed Officer of Ceremonies at the President's Office. In June 1914 he was appointed Chinese Minister to Great Britain. He was one of China's Chief Delegates to the Paris Conference in 1919. In September 1920 he was transferred to be Chinese Minister to Washington. In October 1921 he was awarded the First Class Wenhu and appointed a Chief Delegate to the Washington Conference. In November 1921 he was given the rank of Ambassador. In March 1922 and October 1922 he was awarded respectively the First Class Tashou Chiaho and the First Class Tashou Paokuang Chiaho. Mr. Sze visited China in November 1922. He was nominated as Minister of Foreign Afairs but rejected by the Senate, in January 1923. However, he was acting Minister of Foreign Affairs from January 5 to February 3, 1923. Subsequently he was awarded the Second Order of Merit. He returned to the Washington Post in 1923. In July 1924 he was ordered to be Chinese delegate to the International Opium Conference held under the League of Nations. At this conference Dr. Sze made a strong fight supported by the American delegation to bring about the complete suppression of the opium production and manufacturing, except for medical purposes. Finally at the session in 1925, when the matter was brought to a vote and no affirmative action taken, the American and Chinese delegates left the Conference. Dr. Sze returned to his post in Washington.