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great forwardnesse for running mad, by ouer-watching himselfe, the coldnesse and moistnesse of our braine beeing the onely ordinarie meanes that procure our sleepe and rest. Indeed I do not denie, but when it falls out that any of these, or any part of our bodie growes to be distempered, and to tend to an extremitie, beyond the compasse of Natures temperate mixture, that in that case cures of contrary qualities, to the intemperate inclination of that part, being wisely prepared and discreetely ministered, may be both necessarie and helpefull for strengthning and assisting Nature in the expulsion of her enemies: for this is the true definition of all profitable Physicke.

But first these Cures ought not to bee vsed, but where there is neede of them, the contrarie where of, is daily practised in this generall vse of Tobacco by all sorts and complexions of people.

And next, I deny the minor of this argument, as I haue already said, in regard that this Tobacco, is not simply of a hot and dry qualitie; but rather hath a certaine venemous facultie ioyned with the heate thereof, which makes it haue an Antipathie against nature, as by the hatefull smell thereof doeth well appeare. For the nose being the proper Organ and convoy of the sense of smelling to the braines, which are the onely fountaine of that sense, doeth euer serue vs for an infallible witnesse, whether that Odour which we smell, be healthfull or hurtfull to the braine (except when it fals out