the amœboid movement is usually more sluggish [we have, however, seen it most remarkably active]; the pigment granules are coarser and blacker. The containing red corpuscle appears a shade darker than the surrounding ones, and is a trifle smaller. As sporulation approaches, the pigment makes its way to the centre, and 6 to 12 segments or spores form, very regularly arranged in daisy-like form, therein differing from benign tertian. The gamete is also spherical, but rather smaller than the benign tertian gamete.
Sub-tertian ring-forms are smaller than either benign tertian or quartan; they show active movement in the early stages and usually are seen towards the periphery of the red corpuscle or actually on it. The pigment is very fine and scanty. The sporocyte only occurs in deep blood. The gamete is crescentic in outline, therein differing from the spherical gametes of benign tertian and quartan.
The polymorphonuclear and large mononuclear leucocytes may contain ingested pigment, and occasionally, in quartan, a red corpuscle containing a parasite.
If quinine has been administered no parasites may be found in the blood, except the crescents of sub-tertian.
