ANILINE, o-TOLUIDINE, AND NITROBENZENE: METHOD 2017, Issue 1, dated 15 January 1998 - Page 4 of 5
Desorption efficiency (DE) for aniline (recovered from acid-treated filters) was determined to be 1.00 at 10 × LOD [1]. Aniline storage stability at 0.12 mg was 64% after 7 days [1]; however, at 0.2 to 0.7 mg recovery was 93.8% [2]. (Recoveries for storage stability samples must be 90% to be acceptable.) Aniline recovery from gauze wipes spiked and air equilibrated for 8 hours was 83% with a precision of 0.048, while recovery from passive dermal samplers, spiked and air equilibrated for 1 hour, was 88% [1]. Desorption efficiency (DE) for o-toluidine (recovered from acid treated filters) was determined to be 1.00 at 10 × LOD [1]. o-Toluidine storage stability at 0.6 to 2.5 mg was 96.3% after 7 days [2], but at 0.1 mg was 76% [1]. o-Toluidine recovery from gauze wipes spiked and air equilibrated for 8 hours was 88% with a precision of 0.039, while recovery from passive dermal samplers, spiked and air equilibrated for 1 hour, was 95% [1]. Desorption efficiency (DE) for nitrobenzene (recovered from silica gel tubes) was determined to be 98% at 10 × LOD [1]. Nitrobenzene storage stability at 0.12 mg was acceptable after 60 days with a 95% recovery [1]. Nitrobenzene recovery from gauze wipes, spiked and air equilibrated for < 1 hour, was 89% with a precision of 0.092, while recovery from passive dermal samplers spiked and air equilibrated for 24 hours was > 92% [1]. REFERENCES: [1] Pendergrass SM [1994]. An approach for estimating workplace exposure to o-toluidine, aniline, and nitrobenzene. Am Ind Hyg Assoc J 55:733–737. [2] NIOSH [1977]. Documentation of NIOSH Validation Tests, S168, S217, S310. Cincinnati, OH: National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 77-185. [3] NIOSH [1994]. Aromatic Amines: Method 2002. In: Eller PM, Cassinelli ME, eds. NIOSH Manual of Analytical Methods, 4th ed. Cincinnati, OH: National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 94-113. [4] NIOSH [1994]. Nitrobenzenes: Method 2005. In: Eller PM, Cassinelli ME, eds. NIOSH Manual of Analytical Methods, 4th ed. Cincinnati, OH: National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 94-113. [5] Ward E, Carpenter A, Roberts D, et al. [1991]. Excess number of bladder cancers in workers exposed to ortho-toluidine and aniline. J Natl Cancer Inst 83(7):501–506. [6] NIOSH [1990]. NIOSH Alert: preventing bladder cancer from exposure to o-toluidine and aniline. Cincinnati, OH: National Institute for Occupational Safety Health, DHHS (NIOSH) Publication No. 90116; NTIS No. PB-91-188-953. METHOD WRITTEN BY: Stephanie M. Pendergrass, NIOSH/DPSE
NIOSH Manual of Analytical Methods (NMAM), Fourth Edition
