NITROSAMINES
Table 1
MW: Table 1
METHOD: 2522, Issue 2
2522
CAS: Table 1
RTECS: Table 1
EVALUATION: PARTIAL
OSHA : no PELs; N-nitrosodimethylamine is a carcinogen NIOSH: no RELs; N-nitrosodimethylamine is suspect carcinogen ACGIH: no TLVs; N-nitrosodimethylamine is suspect carcinogen
Issue 1: 15 May 1989 Issue 2: 15 August 1994
PROPERTIES: Table 1
SYNONYMS: Table 1.
SAMPLING SAMPLER:
SOLID SORBENT TUBE (Thermosorb/N™ air sampler)
FLOW RATE:
0.2 to 2 L/min
VOL-MIN: -MAX:
15 L @ 10 µg/m 3 1000 L
SHIPMENT:
routine
SAMPLE STABILITY:
at least 6 weeks @ 20 °C [1,2]
BLANKS:
2 to 10 field blanks per set
MEASUREMENT TECHNIQUE:
GAS CHROMATOGRAPHY, TEA [1]
ANALYTE:
nitrosamines (Table 1)
DESORPTION:
2 mL 3:1 (v/v) dichloromethane/ methanol; stand 30 min
INJECTION VOLUME: COLUMN:
5 µL stainless steel (10 in x in ); 10% Carbowax 20M + 2% KOH on Chromosorb W-AW
TEMPERATURE-INJECTION: -DETECTOR: -COLUMN:
GASES:
N 2 carrier, 25 mL/min; oxygen, 5 mL/min; ozone, 0.2 mL/min
CALIBRATION:
standard solutions of analytes in methanol/dichloromethane
RANGE:
0.15 to 0.5 µg per sample [2]
ACCURACY RANGE STUDIED:
not studied
BIAS:
not determined
200 °C 550 °C to 600 °C 110 °C to 200 °C programmed @ 5°/min
ˆ ): not determined OVERALL PRECISION (S rT ESTIMATED LOD: 0.05 µg per sample [2] ACCURACY:
not determined PRECISION (Sr):
0.014 @ 0.05 to 0.4 µg per sample [2]
APPLICABILITY: The working range is 0.003 to 10 mg/m 3 for a 50-L air sample. If high ambient concentrations of nitrosamines are expected, another Thermosorb/N tube should be used as a back-up in sampling.
INTERFERENCES: When the thermal energy analyzer (TEA) is operated in the nitrosamine mode, it is highly specific for N-nitroso compounds. Because of the TEA's selectivity and sensitivity, it is possible to chromatograph and quantitate N-nitroso compounds, even in the presence of other co-eluting compounds. Therefore, there is little or no interference from other compounds.
OTHER METHODS: This replaces NIOSH methods P&CAM 252 [3] and P&CAM 299 [4].
NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94
