DIMETHYL SULFATE
(CH3O)2SO2
MW: 126.13
METHOD: 2524, Issue 2
2524
CAS: 77-78-1
RTECS: WS8225000
EVALUATION: PARTIAL
OSHA : 0.1 ppm (skin) NIOSH: 0.1 ppm/8 hours (skin); carcinogen ACGIH: 0.1 ppm (skin); suspect carcinogen (1 ppm = 5.16 mg/m 3 @ NTP)
Issue 1: 15 May 1985 Issue 2: 15 August 1994
PROPERTIES: liquid; d 1.332 g/mL @ 20 C; BP 188 °C with decomposition; MP -31.8 °C; VP 0.07 kPa (0.5 mm Hg; 700 ppm) @ 20 °C
SYNONYMS: methyl sulfate
SAMPLING SAMPLER:
SOLID SORBENT TUBE (Poropak P, 100 mg/50 mg)
FLOW RATE:
0.01 to 0.2 L/min
VOL-MIN: -MAX:
0.25 L @ 1 ppm 12 L
SAMPLE STABILITY:
at least 1 week @ 25 °C [1]
BLANKS:
2 to 10 field blanks per set
MEASUREMENT TECHNIQUE:
GAS CHROMATOGRAPHY, ELECTROLYTIC CONDUCTIVITY DETECTOR (SULFUR MODE)
ANALYTE:
dimethyl sulfate
DESORPTION:
1 mL diethyl ether, 30 min
INJECTION VOLUME:
TEMPERATURE-INJECTION: -COLUMN:
1.8 to 24.5 mg/m 3 [1] (1.2-L samples)
BIAS:
see EVALUATION OF METHOD
ˆ ): 0.073 [1] OVERALL PRECISION (S rT ACCURACY:
not determined
180 °C 2 min @ 50 °C; then 30 °C/min to 120 °C; hold
CARRIER GAS:
He, 20 mL/min
COLUMN:
1.8 m x 3.2-mm OD stainless steel, packed with 5% DEGS on 80/100 mesh Chromosorb WHP
CALIBRATION:
dimethyl sulfate in diethyl ether
RANGE:
1 to 120 µg per sample
ACCURACY RANGE STUDIED:
4 µL
ESTIMATED LOD: 0.25 µg per sample [1] PRECISION (Sr):
0.06 @ 1.1 to 39 µg per sample [1]
APPLICABILITY: The working range is 0.03 to 4 ppm (0.17 to 20 mg/m 3) for a 6-L air sample.
INTERFERENCES: None identified.
OTHER METHODS: This revises P&CAM 301 [2].
NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94
