THIRAM
((CH3)2NC(=S)S-)2
MW: 240.43
METHOD: 5005, Issue 2
5005
CAS: 137-26-8
RTECS: JO1400000
EVALUATION: FULL
OSHA : 5 mg/m 3 NIOSH: 5 mg/m 3; Group I Pesticide ACGIH: 1 mg/m 3
PROPERTIES:
Issue 1: 15 February 1984 Issue 2: 15 August 1994
white crystalline powder; d 1.29 g/mL; MP 155 °C; VP not significant
SYNONYMS: bis(dimethylthiocarbamoyl)disulfide; tetramethylthiuram disulfide; tetramethylthioperoxydicarbonic diamide
SAMPLING SAMPLER:
FILTER (1-µm PTFE membrane)
FLOW RATE:
1 to 4 L/min
VOL-MIN: -MAX:
10 L 400 L
SHIPMENT:
routine
SAMPLE STABILITY:
7 days at 25 °C
BLANKS:
2 to 10 field blanks per set
BULK SAMPLE:
desirable; 1 to 5g
MEASUREMENT TECHNIQUE:
HPLC, UV DETECTION
ANALYTE:
Thiram
EXTRACTION:
(filter) 10 mL CH 3CN, 30 min; (cassette top) 10 mL CH 3CN rinse
INJECTION VOLUME:
5 µL
MOBILE PHASE:
60% acetonitrile/40% water, 1 mL/min
COLUMN:
µ-Bondapak C 18 (30 cm x 3.9-mm-ID stainless steel); ambient temperature
DETECTOR:
UV @ 254 nm, 1-cm cell
CALIBRATION:
standard solutions of Thiram in acetonitrile
RANGE:
0.1 to 3 mg per sample [1]
ACCURACY RANGE STUDIED:
3 to 12 mg/m 3 [1] (240-L samples)
BIAS:
- 0.18%
ˆ ): 0.055 [1] OVERALL PRECISION (S rT ACCURACY:
ESTIMATED LOD: 0.005 mg per sample [1] PRECISION (Sr):
0.012 [1]
± 10.67%
APPLICABILITY: The working range is 0.5 to 15 mg/m 3 for a 200-L air sample. NIOSH researchers have used this method at facilities that use Thiram as an insecticide.
INTERFERENCES: None known.
OTHER METHODS: This is Method S256 [2] in a revised format. An earlier spectrophotometric method, P&CAM 228 [3], has not been revised because of excessive analytical variability [4].
NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94
