METALS in Urine
TABLE 1
MW: Table 1
METHOD: 8310, Issue 2
CAS: Table 1
8310
RTECS: Table 1
EVALUATION: PARTIAL
Issue 1: 15 February 1984 Issue 2: 15 August 1994
BIOLOGICAL INDICATOR OF: exposure to the following metals or their compounds: aluminum, barium, cadmium, chromium, copper, iron, lead, manganese, molybdenum, nickel, platinum, silver, strontium, tin, titanium, and zinc.
SYNONYMS: vary according to the compound
SAMPLING
MEASUREMENT
SPECIMEN:
urine
VOLUME:
50 to 200 mL in polyethylene bottle
PRESERVATIVE: 5.0 mL conc. collection
HNO 3
added
after
SHIPMENT:
frozen in dry ice
STABILITY:
not established
CONTROLS:
collect at least 3 urine specimens from unexposed workers
TECHNIQUE:
INDUCTIVELY-COUPLED ARGON PLASMA, ATOMIC EMISSION SPECTROSCOPY (ICP-AES)
ANALYTE:
elements above
EXTRACTION MEDIA:
polydithiocarbamate resin
FINAL SOLUTION:
4% HNO 3, 1% HClO 4; 5 mL
WAVELENGTH:
depends upon element; Table 2
BACKGROUND CORRECTION:
spectral wavelength shift
CALIBRATION:
elements in 4% HNO 3, 1% HClO 4
QUALITY CONTROL:
spiked urines; corrected for creatinine
RANGE:
0.25 to 200 µg per sample [1]
ESTIMATED LOD: 0.1 µg per sample PRECISION (Sr):
Table 2
ACCURACY:
Table 2
APPLICABILITY: This method measures urine concentrations of metals. It is particularly useful for workers exposed to several metals simultaneously. This is a simultaneous, multielemental analysis, but is not compound specific.
INTERFERENCES: Spectral interferences are the primary interferences encountered in ICP-AES analysis. These are minimized by judicious wavelength selection and interelement correction factors. Background corrections are also made [1,2].
OTHER METHODS: This method uses a measurement technique similar to that of Method 7300 (Elements by ICP) for air samples.
NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94
