METHAMPHETAMINE . . .on Wipes by Liquid-Liquid Extraction: METHOD 9106, Issue 1, dated 17 October 2011 - Page 17 of 31
Table 8a. Precision and accuracy in scan mode.(1) Compound (D)-Amphetamine
Caffeine
(L)-Ephedrine MDEA MDMA
(D)-Methamphetamine
Phencyclidine
Phentermine (±)-Norephedrine(4) Pseudoephedrine
Internal Standard(2)
Range(3) µg/sample Accuracy
D11-Amp D14-Met NMPhen D11-Amp D14-Met NMPhen D11-Amp D14-Met NMPhen N-PAmp D11-Amp D14-Met NMPhen D11-Amp D14-Met NMPhen D11-Amp D14-Met NMPhen D11-Amp D14-Met NMPhen
0.1-30 0.1-30 0.1-30 1.0-30 1.0-30 1.0-30 0.1-10 0.3-10 0.3-30 0.3-29 0.3-27 0.3-27 0.3-27 0.1-30 0.1-30 0.1-10(5) 0.1-10 0.3-3 0.3-10 0.1-30 0.1-30 0.1-30
D11-Amp D11-Amp D14-Met NMPhen
1-30 0.3-30 0.3-30 0.3-30
17.1 13.7 12.5 20.0 12.5 15.6 15.4 17.8 15.0 16.6 20.2 16.6 22.0 14.7 12.5 14.9 18.2 13.4 16.8 15.2 10.7 9.6 6.5 17.2 14.9 18.7
Bias
Overall Precision
Average
Range
0.0670 0.0610 0.0559 0.0708 0.0636 0.0796 0.0627 0.0674 0.0707 0.0817 0.0778 0.0652 0.0722 0.0631 0.0546 0.0503 0.0690 0.0465 0.0609 0.0486 0.0509 0.0420 0.0328 0.0571 0.0649 0.0488
-0.0613 +0.0338 -0.0310 -0.0832 -0.0014 -0.0040 +0.0510 +0.0666 +0.0293 -0.0224 -0.0739 +0.0589 -0.1017 -0.0435 -0.0348 -0.0665 -0.0683 -0.0577 -0.0682 -0.0720 +0.0190 -0.0269 +0.0061 -0.0783 -0.0422 -0.1068
-0.1048 - -0.0170 -0.0151 - +0.1056 -0.0651 - +0.0177 - 0.1476 - -0.0542 - 0.0274 - +0.0381 -0.0789 - +0.1321 -0.0148 - +0.1128 +0.0261 - +0.1660 -0.0259 - +0.0973 -0.0656 - +0.0657 -0.1011 - -0.0489 -0.0947 - +0.0036 -0.1486 - -0.0315 -0.0657 - -0.0060 -0.1144 - +0.0188 -0.1179 - +0.0110 -0.1257 - -0.0136 -0.0662 - -0.0493 -0.1137 - +0.0091 -0.1010 - +0.0291 -0.0395 - +0.0671 -0.0612 - +0.0340 -0.0070 - +0.0248 -0.1273 - -0.0560 -0.0888 - +0.0395 -0.1505 - -0.0422
(1) Backup Data Report [1]. Values are for chlorodifluoroacetyl derivatives and analysis by GC-MS in scan mode. Each sample consisted of a pair of 3” x 3” 12-ply cotton gauze pads. There were 6 replicate samples per concentration level and six concentration levels evaluated from approximately 0.1 to 30 µg/sample. (2) Internal Standards Deuterated: Non-deuterated:
D11-Amp = Amphetamine-D11 NMPhen = N-Methyl phenethylamine
D14-Met = Methamphetamine-D14
N-PAmp = N-Propyl amphetamine
(3) Range used for calculation of precision, accuracy, and bias. The entire range studied for all analytes was approximately 0.1 to 30 µg/sample (1xLOQ to 300xLOQ). (4) (±)-Norephedrine = (±)-phenylpropanolamine. (5) One or more higher level concentrations were omitted from the computations due to inlier CVs (<0.0200.)
NIOSH Manual of Analytical Methods (NMAM), Fifth Edition
Method rev. 1.1.1
