way he visited, in turn, Greece, Italy, Asia Minor and perhaps also the southern portion of France (the Narbonaise). He collected great quantities of specimens of every kind of drug—animal and mineral substances as well as objects belonging to the vegetable kingdom; and, wherever it was possible to do so, he wrote memoranda of the traditions of the natives with regard to the uses and medicinal effects of these different drugs. After he had completed all these researches and had gathered together all this vast mass of materials, he wrote his famous treatise on materia medica—"the most complete, the best considered, and the most useful work of its kind to be found anywhere to-day." (Galen.) It is from this treatise, therefore, says Dezeimeris, that one can derive the most satisfactory idea of the early Greek materia medica; but at the same time, he adds, it is not a book in which will be found a detailed account of the manner in which the practitioners of that period employed the remedies which he describes. The same authority calls attention to the great difficulty which modern physicians often experience in their attempts to identify the drugs which Dioscorides describes. Le Clerc calls attention to the fact that the physicians who were contemporaries of Dioscorides were not in the habit of employing either iron or antimony (called by them stibium) internally. Apparently they had not yet learned that these substances possess properties which exert a curative action in certain diseases. On the other hand, he mentions the manner of extracting quicksilver, by chemical means, from cinnabar [red sulphide of mercury], the steps required for preparing acetate of lead, and the proper way of making lime water.
The work to which reference has been made above was published by Dioscorides about the year 77 A. D. It is the earliest pharmacological treatise that has come down to our time, and for many succeeding centuries it served as the authoritative guide in all questions relating to drugs. The first printed edition of the Greek original appeared in Venice in 1499, but a still earlier Latin version was issued in 1478. According to Pagel the best edition (in Latin and
