Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
edit- Excludes2: autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O99)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E90)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T98)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
- This chapter contains the following blocks:
- D50-D53 Nutritional anemias
- D55-D59 Hemolytic anemias
- D60-D64 Aplastic and other anemias and other bone marrow failure syndromes
- D65-D69 Coagulation defects, purpura and other hemorrhagic conditions
- D70-D77 Other disorders of blood and blood-forming organs
- D78 Intraoperative and postprocedural complications of spleen
- D80-D89 Certain disorders involving the immune mechanism
Nutritional anemias (D50-D53)
editD50 Iron deficiency anemia
edit- Includes: asiderotic anemia
- hypochromic anemia
- D50.0 Iron deficiency anemia secondary to blood loss (chronic)
- Posthemorrhagic anemia (chronic)
- Excludes1: acute posthemorrhagic anemia (D62)
- congenital anemia from fetal blood loss (P61.3)
- D50.1 Sideropenic dysphagia
- Kelly-Paterson syndrome
- Plummer-Vinson syndrome
- D50.8 Other iron deficiency anemias
- Iron deficiency anemia due to inadequate dietary iron intake
- D50.9 Iron deficiency anemia, unspecified
D51 Vitamin B12 deficiency anemia
edit- Excludes1: vitamin B12 deficiency (E53.8)
- D51.0 Vitamin B12 deficiency anemia due to intrinsic factor deficiency
- Addison anemia
- Biermer anemia
- Pernicious (congenital) anemia
- Congenital intrinsic factor deficiency
- D51.1 Vitamin B12 deficiency anemia due to selective vitamin B12 malabsorption with proteinuria
- Imerslund (-Gr?sbeck) syndrome
- Megaloblastic hereditary anemia
- D51.2 Transcobalamin II deficiency
- D51.3 Other dietary vitamin B12 deficiency anemia
- Vegan anemia
- D51.8 Other vitamin B12 deficiency anemias
- D51.9 Vitamin B12 deficiency anemia, unspecified
D52 Folate deficiency anemia
edit- Excludes1: folate deficiency without anemia (E53.8)
- D52.0 Dietary folate deficiency anemia
- Nutritional megaloblastic anemia
- D52.1 Drug-induced folate deficiency anemia
- Code first (T36-T50) to identify drug
- D52.8 Other folate deficiency anemias
- D52.9 Folate deficiency anemia, unspecified
- Folic acid deficiency anemia NOS
D53 Other nutritional anemias
edit- Includes: megaloblastic anemia unresponsive to vitamin B12 or folate therapy
- D53.0 Protein deficiency anemia
- Amino-acid deficiency anemia
- Orotaciduric anemia
- Excludes1: Lesch-Nyhan syndrome (E79.1)
- D53.1 Other megaloblastic anemias, not elsewhere classified
- Megaloblastic anemia NOS
- Excludes1: Di Guglielmo's disease (C94.0)
- D53.2 Scorbutic anemia
- Excludes1: scurvy (E54)
- D53. 8 Other specified nutritional anemias
- Anemia associated with deficiency of copper
- Anemia associated with deficiency of molybdenum
- Anemia associated with deficiency of zinc
- Excludes1: nutritional deficiencies without anemia, such as:
- copper deficiency NOS (E61.0)
- molybdenum deficiency NOS (E61.5)
- zinc deficiency NOS (E60)
- D53.9 Nutritional anemia, unspecified
- Simple chronic anemia
- Excludes1: anemia NOS (D64.9)
Hemolytic anemias (D55-D59)
editD55 Anemia due to enzyme disorders
edit- Excludes1: drug-induced enzyme deficiency anemia (D59.2)
- D55.0 Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
- Favism
- G6PD deficiency anemia
- D55.1 Anemia due to other disorders of glutathione metabolism
- Anemia (due to) enzyme deficiencies, except G6PD, related to the hexose monophosphate [HMP] shunt pathway
- Anemia (due to) hemolytic nonspherocytic (hereditary), type I
- D55.2 Anemia due to disorders of glycolytic enzymes
- Hemolytic nonspherocytic (hereditary) anemia, type II
- Hexokinase deficiency anemia
- Pyruvate kinase [PK] deficiency anemia
- Triose-phosphate isomerase deficiency anemia
- Excludes1: disorders of glycolysis not associated with anemia (E74.8)
- D55.3 Anemia due to disorders of nucleotide metabolism
- D55.8 Other anemias due to enzyme disorders
- D55.9 Anemia due to enzyme disorder, unspecified
- D56 Thalassemia
- Excludes1: sickle-cell thalassemia (D57.4-)
D56.0 Alpha thalassemia
edit- Alpha thalassemia major
- Hemoglobin H disease
- Severe alpha thalassemia
- Triple gene defect alpha thalassemia
- Excludes1: alpha thalassemia minor (D56.3)
- asymptomatic alpha thalassemia (D56.3)
- hydrops fetalis due to hemolytic disease (P56.-)
- D56.1 Beta thalassemia
- Beta thalassemia major
- Cooley' s anemia
- Homozygous beta thalassemia
- Severe beta thalassemia
- Thalassemia intermedia
- Excludes1: beta thalassemia minor (D56.3)
- delta-beta thalassemia (D56.2)
- sickle-cell beta thalassemia (D57.4-)
- D56.2 Delta-beta thalassemia
- Homozygous delta-beta thalassemia
- Excludes1: delta-beta thalassemia minor (D56.3)
- D56.3 Thalassemia minor
- Alpha thalassemia minor
- Alpha thalassemia trait
- Beta thalassemia minor
- Delta-beta thalassemia minor
- Excludes1: alpha thalassemia (D56.0)
- beta thalassemia (D56.1)
- delta-beta thalassemia (D56.2)
- D56.4 Hereditary persistence of fetal hemoglobin [HPFH]
- D56.8 Other thalassemias
- Hb-Bart's disease
- Excludes1: sickle cell anemia (D57.-)
- sickle-cell thalassemia (D57.4)
- D56.9 Thalassemia, unspecified
- Mediterranean anemia (with other hemoglobinopathy)
- Thalassemia (minor) (mixed) (with other hemoglobinopathy)
D57 Sickle-cell disorders
edit- Use additional code for any associated fever (R50.81)
- Excludes1: other hemoglobinopathies (D58.-)
- D57.0 Hb-SS disease with crisis
- Sickle-cell disease NOS with crisis
- Hb-SS disease with vasoocclusive pain
- D57.00 Hb-SS disease with crisis, unspecified
- D57.01 Hb-SS disease with acute chest syndrome
- D57.02 Hb-SS disease with splenic sequestration
- D57.1 Sickle-cell disease without crisis
- Hb-SS disease without crisis
- Sickle-cell anemia NOS
- Sickle-cell disease NOS
- Sickle-cell disorder NOS
- D57.2 Sickle-cell/Hb-C disease
- Hb-SC disease
- Hb-S/Hb-C disease
- D57.20 Sickle-cell/Hb-C disease without crisis
- D57.21 Sickle-cell/Hb-C disease with crisis
- D57. 211 Sickle-cell/Hb-C disease with acute chest syndrome
- D57.212 Sickle-cell/Hb-C disease with splenic sequestration
- D57.219 Sickle-cell/Hb-C disease with crisis, unspecified
- Sickle-cell/Hb-C disease with crisis NOS
- D57.3 Sickle-cell trait
- Hb-S trait
- Heterozygous hemoglobin S
- D57.4 Sickle-cell thalassemia
- Sickle-cell beta thalassemia
- Thalassemia Hb-S disease
- D57.40 Sickle-cell thalassemia without crisis
- Sickle-cell thalassemia NOS
- D57.41 Sickle-cell thalassemia with crisis
- Sickle-cell thalassemia with vasoocclusive pain
- D57.411 Sickle-cell thalassemia with acute chest syndrome
- D57.412 Sickle-cell thalassemia with splenic sequestration
- D57.419 Sickle-cell thalassemia with crisis, unspecified
- Sickle-cell thalassemia with crisis NOS
- D57.8 Other sickle-cell disorders
- Hb-SD disease
- Hb-SE disease
- D57.80 Other sickle-cell disorders without crisis
- D57.81 Other sickle-cell disorders with crisis
- D57.811 Other sickle-cell disorders with acute chest syndrome
- D57.812 Other sickle-cell disorders with splenic sequestration
- D57.819 Other sickle-cell disorders with crisis, unspecified
- Other sickle-cell disorders with crisis NOS
D58 Other hereditary hemolytic anemias
edit- Excludes1: hemolytic anemia of the newborn (P55.-)
- D58.0 Hereditary spherocytosis
- Acholuric (familial) jaundice
- Congenital (spherocytic) hemolytic icterus
- Minkowski-Chauffard syndrome
- D58.1 Hereditary elliptocytosis
- Elliptocytosis (congenital)
- Ovalocytosis (congenital) (hereditary)
- D58.2 Other hemoglobinopathies
- Abnormal hemoglobin NOS
- Congenital Heinz body anemia
- Hb-C disease
- HbD disease
- Hb-E disease
- Hemoglobinopathy NOS
- Unstable hemoglobin hemolytic disease
- Excludes1: familial polycythemia (D75.0)
- Hb-M disease (D74.0)
- hereditary persistence of fetal hemoglobin [HPFH] (D56.4)
- high-altitude polycythemia (D75.1)
- methemoglobinemia (D74.-)
- D58.8 Other specified hereditary hemolytic anemias
- D58.9 Hereditary hemolytic anemia, unspecified
D59 Acquired hemolytic anemia
edit- D59.0 Drug-induced autoimmune hemolytic anemia
- Code first (T36-T50) to identify drug
- D59.1 Other autoimmune hemolytic anemias
- Autoimmune hemolytic disease (cold type) (warm type)
- Chronic cold hemagglutinin disease
- Cold agglutinin disease
- Cold agglutinin hemoglobinuria
- Cold type (secondary) (symptomatic) hemolytic anemia
- Warm type (secondary) (symptomatic) hemolytic anemia
- Excludes1: Evans syndrome (D69.41)
- hemolytic disease of newborn (P55.-)
- paroxysmal cold hemoglobinuria (D59.6)
- D59.2 Drug-induced nonautoimmune hemolytic anemia
- Drug-induced enzyme deficiency anemia
- Code first (T36-T50) to identify drug
- D59.3 Hemolytic-uremic syndrome
- D59.4 Other nonautoimmune hemolytic anemias
- Mechanical hemolytic anemia
- Microangiopathic hemolytic anemia
- Toxic hemolytic anemia
- D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
- Excludes1: hemoglobinuria NOS (R82.3)
- D59.6 Hemoglobinuria due to hemolysis from other external causes
- Hemoglobinuria from exertion
- March hemoglobinuria
- Paroxysmal cold hemoglobinuria
- Use additional code (Chapter 20) to identify external cause
- Excludes1: hemoglobinuria NOS (R82.3)
- D59.8 Other acquired hemolytic anemias
- D59.9 Acquired hemolytic anemia, unspecified
- Idiopathic hemolytic anemia, chronic
Aplastic and other anemias and other bone marrow failure syndromes (D60-D64)
D60 Acquired pure red cell aplasia [erythroblastopenia]
edit- Includes: red cell aplasia (acquired) (adult) (with thymoma)
- Excludes1: congenital red cell aplasia (D61.01)
- D60.0 Chronic acquired pure red cell aplasia
- D60.1 Transient acquired pure red cell aplasia
- D60.8 Other acquired pure red cell aplasias
- D60.9 Acquired pure red cell aplasia, unspecified
D61 Other aplastic anemias and other bone marrow failure syndromes
edit- Excludes1: neutropenia (D70.-)
- D61.0 Constitutional aplastic anemia
- D61.01 Constitutional (pure) red blood cell aplasia
- Excludes1: acquired red cell aplasia (D60.9)
- Blackfan-Diamond syndrome
- Congenital (pure) red cell aplasia
- Familial hypoplastic anemia
- Primary (pure) red cell aplasia
- Red cell (pure) aplasia of infants
- D61.09 Other constitutional aplastic anemia
- Fanconi's anemia
- Pancytopenia with malformations
- D61.1 Drug-induced aplastic anemia
- Code first (T36-T50) to identify drug
- D61.2 Aplastic anemia due to other external agents
- Code first (T51-T65) to identify cause
- D61.3 Idiopathic aplastic anemia
- D61.8 Other specified aplastic anemias and other bone marrow failure syndromes
- D61.81 Pancytopenia
- Excludes1: pancytopenia (due to) (with):
- aplastic anemia (D61.-)
- bone marrow infiltration (D61.82)
- congenital (pure) red cell aplasia (D61.01)
- drug induced (D61.1)
- hairy cell leukemia (C91.4-)
- human immunodeficiency virus disease (B20.-)
- leukoerythroblastic anemia (M61.82)
- myelodysplastic syndromes (D46.-)
- myeloproliferative disease (D47.1)
- D61.82 Myelophthisis
- Leukoerythroblastic anemia
- Myelophthisic anemia
- Panmyelophthisis
- Code also the underlying disorder, such as:
- malignant neoplasm of breast (C50.-)
- tuberculosis (A15.-)
- Excludes1: idiopathic myelofibrosis (D47.1)
- myelofibrosis NOS (D75.81)
- myelofibrosis with myeloid metaplasia (D47.4)
- primary myelofibrosis (D47.1)
- secondary myelofibrosis (D75.81)
- D61.89 Other specified aplastic anemias and other bone marrow failure syndromes
- D61.9 Aplastic anemia, unspecified
- Hypoplastic anemia NOS
- Medullary hypoplasia
D62 Acute posthemorrhagic anemia
edit- Excludes1: anemia due to chronic blood loss (D50.0)
- blood loss anemia NOS (D50.0)
- congenital anemia from fetal blood loss (P61.3)
D63 Anemia in chronic diseases classified elsewhere
edit- D63.0 Anemia in neoplastic disease
- Code first neoplasm (C00-D49)
- Excludes1: anemia due to antineoplastic chemotherapy (D64.81)
- D63.1 Anemia in chronic kidney disease
- Erythropoietin resistant anemia (EPO resistant anemia)
- Code first underlying chronic kidney disease (CKD) (N18.-)
- D63.8 Anemia in other chronic diseases classified elsewhere
- Code first underlying disease, such as:
- diphyllobothriasis (B70.0)
- hookworm disease (B76.0-B76.9)
- hypothyroidism (E00.0-E03.9)
- malaria (B50.0-B54)
- symptomatic late syphilis (A52.79)
- tuberculosis (A18.89)
- Code first underlying disease, such as:
D64 Other anemias
edit- Excludes1: refractory anemia (D46.-)
- D64.0 Hereditary sideroblastic anemia
- Sex-linked hypochromic sideroblastic anemia
- D64.1 Secondary sideroblastic anemia due to disease
- Code first underlying disease
- D64.2 Secondary sideroblastic anemia due to drugs and toxins
- Code first (T36-T65) to identify drug or toxin
- D64. 3 Other sideroblastic anemias
- Sideroblastic anemia NOS
- Pyridoxine-responsive sideroblastic anemia NEC
- D64.4 Congenital dyserythropoietic anemia
- Dyshematopoietic anemia (congenital)
- Excludes1: Blackfan-Diamond syndrome (D61.01)
- Di Guglielmo's disease (C94.0)
- D64.8 Other specified anemias
- D64.81 Anemia due to antineoplastic chemotherapy
- Antineoplastic chemotherapy induced anemia
- Excludes1: anemia in neoplastic disease (D63.0)
- aplastic anemia due to antineoplastic chemotherapy (D61.1)
- D64.89 Other specified anemias
- Infantile pseudoleukemia
- D64.81 Anemia due to antineoplastic chemotherapy
- D64.9 Anemia, unspecified
Coagulation defects, purpura and other hemorrhagic conditions (D65-D69)
editD65 Disseminated intravascular coagulation [defibrination syndrome]
edit- Includes: afibrinogenemia, acquired
- consumption coagulopathy
- diffuse or disseminated intravascular coagulation [DIC]
- fibrinolytic hemorrhage, acquired
- fibrinolytic purpura
- purpura fulminans
- Excludes1: disseminated intravascular coagulation (complicating):
- abortion or ectopic or molar pregnancy (O00-O07, O08.1)
- in newborn (P60)
- pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)
D66 Hereditary factor VIII deficiency
edit- Includes: classical hemophilia
- deficiency factor VIII (with functional defect)
- hemophilia NOS
- hemophilia A
- Excludes1: factor VIII deficiency with vascular defect (D68.0)
D67 Hereditary factor IX deficiency
edit- Includes: christmas disease
- factor IX deficiency (with functional defect)
- hemophilia B
- plasma thromboplastin component [PTC] deficiency
D68 Other coagulation defects
edit- Excludes1: abnormal coagulation profile (R79.1)
- coagulation defects complicating:
- abortion or ectopic or molar pregnancy (O00-O07, O08.1)
- pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)
D68.0 Von Willebrand's disease
edit- Angiohemophilia
- Factor VIII deficiency with vascular defect
- Vascular hemophilia
- Excludes1: capillary fragility (hereditary) (D69.8)
- factor VIII deficiency NOS (D66)
- factor VIII deficiency with functional defect (D66)
- D68.1 Hereditary factor XI deficiency
- Hemophilia C
- Plasma thromboplastin antecedent [PTA] deficiency
- Rosenthal?s disease
- D68.2 Hereditary deficiency of other clotting factors
- AC globulin deficiency
- Congenital afibrinogenemia
- Deficiency of factor I [fibrinogen]
- Deficiency of factor II [prothrombin]
- Deficiency of factor V [labile]
- Deficiency of factor VII [stable]
- Deficiency of factor X [Stuart-Prower]
- Deficiency of factor XII [Hageman]
- Deficiency of factor XIII [fibrin stabilizing]
- Dysfibrinogenemia (congenital)
- Hypoproconvertinemia
- Owren's disease
- Proaccelerin deficiency
- D68.3 Hemorrhagic disorder due to circulating anticoagulants
- D68.31 Hemorrhagic disorder due to intrinsic circulating anticoagulants
- Hemorrhagic disorder due to intrinsic increase in antithrombin
- Hemorrhagic disorder due to intrinsic increase in anti-VIIIa
- Hemorrhagic disorder due to intrinsic increase in anti-IXa
- Hemorrhagic disorder due to intrinsic increase in anti-Xa
- Hemorrhagic disorder due to intrinsic increase in anti-XIa
- Hyperheparinemia
- D68.32 Hemorrhagic disorder due to extrinsic circulating anticoagulants
- Drug-induced hemorrhagic disorder
- Code first (T45.5-) to identify any administered anticoagulant
- D68.31 Hemorrhagic disorder due to intrinsic circulating anticoagulants
- D68.4 Acquired coagulation factor deficiency
- Deficiency of coagulation factor due to liver disease
- Deficiency of coagulation factor due to vitamin K deficiency
- Excludes1: vitamin K deficiency of newborn (P53)
- D68.5 Primary thrombophilia
- Primary hypercoagulable states
- Excludes1: lupus anticoagulant (D68.62)
- thrombotic thrombocytopenic purpura (M31.1)
- D68.51 Activated protein C resistance
- Factor V Leiden mutation
- D68.52 Prothrombin gene mutation
- D68.59 Other primary thrombophilia
- Antithrombin III deficiency
- Hypercoagulable state NOS
- Primary hypercoagulable state NEC
- Primary thrombophilia NEC
- Protein C deficiency
- Protein S deficiency
- Thrombophilia NOS
- D68.6 Other thrombophilia
- Other hypercoagulable states
- Excludes1: diffuse or disseminated intravascular coagulation [DIC] (D65)
- heparin induced thrombocytopenia (HIT) (D75.82)
- hyperhomocysteinemia (E72.11)
- D68.61 Anticardiolipin syndrome
- Antiphospholipid syndrome
- Excludes1: lupus anticoagulant syndrome (D68.62)
- D68.62 Lupus anticoagulant syndrome
- Lupus anticoagulant
- Presence of systemic lupus erythematosus [SLE] inhibitor
- Excludes1: anticardiolipin syndrome (D68.61)
- antiphospholipid syndrome (D68.61)
- D68.69 Other thrombophilia
- Hypercoagulable states NEC
- Secondary hypercoagulable state NOS
- D68.8 Other specified coagulation defects
- Excludes1: hemorrhagic disease of newborn (P53)
- D68.9 Coagulation defect, unspecified
D69 Purpura and other hemorrhagic conditions
edit- Excludes1: benign hypergammaglobulinemic purpura (D89.0)
- cryoglobulinemic purpura (D89.1)
- essential (hemorrhagic) thrombocythemia (D47.3)
- hemorrhagic thrombocythemia (D47.3)
- purpura fulminans (D65)
- thrombotic thrombocytopenic purpura (M31.1)
- Waldenström's hypergammaglobulinemic purpura (D89.0)
- D69. 0 Allergic purpura
- Allergic vasculitis
- Nonthrombocytopenic hemorrhagic purpura
- Nonthrombocytopenic idiopathic purpura
- Purpura anaphylactoid
- Purpura Henoch(-Sch?nlein)
- Purpura rheumatica
- Vascular purpura
- Excludes1: thrombocytopenic hemorrhagic purpura (D69.3)
- D69.1 Qualitative platelet defects
- Bernard-Soulier [giant platelet] syndrome
- Glanzmann's disease
- Grey platelet syndrome
- Thromboasthenia (hemorrhagic) (hereditary)
- Thrombocytopathy
- Excludes1: von Willebrand's disease (D68.0)
- D69.2 Other nonthrombocytopenic purpura
- Purpura NOS
- Purpura simplex
- Senile purpura
- D69.3 Immune thrombocytopenic purpura
- Hemorrhagic (thrombocytopenic) purpura
- Idiopathic thrombocytopenic purpura
- Tidal platelet dysgenesis
- D69.4 Other primary thrombocytopenia
- Excludes1: transient neonatal thrombocytopenia (P61.0)
- Wiskott-Aldrich syndrome (D82.0)
- D69.41 Evans syndrome
- D69.42 Congenital and hereditary thrombocytopenia purpura
- Congenital thrombocytopenia
- Hereditary thrombocytopenia
- Code first: congential or hereditary disorder, such as:
- thrombocytopenia with absent radius (TAR syndrome) (Q87.2)
- D69.49 Other primary thrombocytopenia
- Megakaryocytic hypoplasia
- Primary thrombocytopenia NOS
- Excludes1: transient neonatal thrombocytopenia (P61.0)
- D69.5 Secondary thrombocytopenia
- Excludes1: heparin induced thrombocytopenia (HIT) (D75.82)
- transient thrombocytopenia of newborn (P61.0)
- Excludes1: heparin induced thrombocytopenia (HIT) (D75.82)
- D69.6 Thrombocytopenia, unspecified
- D69.8 Other specified hemorrhagic conditions
- Capillary fragility (hereditary)
- Vascular pseudohemophilia
- D69.9 Hemorrhagic condition, unspecified
Other disorders of blood and blood-forming organs (D70-D77)
D70 Neutropenia
edit- Includes: agranulocytosis
- decreased absolute neurophile count (ANC)
- Use additional code for any associated:
- fever (R50.81)
- mucositis (J34.81, K12.3-, K12.4, K92.81, N76.81)
- Excludes1: neutropenic splenomegaly (D73.81)
- transient neonatal neutropenia (P61.5)
- D70.0 Congenital agranulocytosis
- Congenital neutropenia
- Infantile genetic agranulocytosis
- Kostmann's disease
- D70.1 Agranulocytosis secondary to cancer chemotherapy
- Code first (T45.1-) to identify drug
- Code also underlying neoplasm
- D70.2 Other drug-induced agranulocytosis
- Code first (T36-T50) to identify drug
- D70.3 Neutropenia due to infection
- D70.4 Cyclic neutropenia
- Cyclic hematopoiesis
- Periodic neutropenia
- D70.8 Other neutropenia
- D70.9 Neutropenia, unspecified
D71 Functional disorders of polymorphonuclear neutrophils
edit- Includes: cell membrane receptor complex [CR3] defect
- chronic (childhood) granulomatous disease
- congenital dysphagocytosis
- progressive septic granulomatosis
D72 Other disorders of white blood cells
edit- Excludes1: basophilia (D72.824)
- immunity disorders (D80-D89)
- neutropenia (D70)
- preleukemia (syndrome) (D46.9)
- D72.0 Genetic anomalies of leukocytes
- Alder (granulation) (granulocyte) anomaly
- Alder syndrome
- Hereditary leukocytic hypersegmentation
- Hereditary leukocytic hyposegmentation
- Hereditary leukomelanopathy
- May-Hegglin (granulation) (granulocyte) anomaly
- May-Hegglin syndrome
- PelgerHu?t (granulation) (granulocyte) anomaly
- Pelger-Hu?t syndrome
- Excludes1: Chediak (-Steinbrinck)-Higashi syndrome (E70.330)
- D72.1 Eosinophilia
- Allergic eosinophilia
- Hereditary eosinophilia
- Excludes1: Löffler's syndrome (J82)
- pulmonary eosinophilia (J82)
- D72.8 Other specified disorders of white blood cells
- Excludes1: leukemia (C91-C95)
- D72.81 Decreased white blood cell count
- Excludes1: neutropenia (D70.-)
- D72.810 Lymphocytopenia
- Decreased lymphocytes
- D72.818 Other decreased white blood cell count
- Basophilic leukopenia
- Eosinophilic leukopenia
- Monocytopenia
- Other decreased leukocytes
- Plasmacytopenia
- D72.819 Decreased white blood cell count, unspecified
- Decreased leukocytes, unspecified
- Leukocytopenia, unspecified
- Leukopenia
- Excludes1: malignant leukopenia (D70.9)
- D72.82 Elevated white blood cell count
- Excludes1: eosinophilia (D72.1)
- D72.820 Lymphocytosis (symptomatic)
- Elevated lymphocytes
- D72.821 Monocytosis (symptomatic)
- Excludes1: infectious mononucleosis (B27.-)
- D72.822 Plasmacytosis
- D72.823 Leukemoid reaction
- Basophilic leukemoid reaction
- Leukemoid reaction NOS
- Lymphocytic leukemoid reaction
- Monocytic leukemoid reaction
- Myelocytic leukemoid reaction
- Neutrophilic leukemoid reaction
- D72.824 Basophilia
- D72.825 Bandemia
- Bandemia without diagnosis of specific infection
- Excludes1: confirmed infection - code to infection
- leukemia (C91.-, C92.-, C93.-, C94.-, C95.-)
- D72.828 Other elevated white blood cell count
- D72.829 Elevated white blood cell count, unspecified
- Elevated leukocytes, unspecified
- Leukocytosis, unspecified
- D72.89 Other specified disorders of white blood cells
- Abnormality of white blood cells NEC
- D72.9 Disorder of white blood cells, unspecified
- Abnormal leukocyte differential NOS
D73 Diseases of spleen
edit- D73.0 Hyposplenism
- Atrophy of spleen
- Excludes1: asplenia (congenital) (Q89.01)
- postsurgical absence of spleen (Z90.81)
- D73.1 Hypersplenism
- Excludes1: neutropenic splenomegaly (D73.81)
- primary splenic neutropenia (D73.81)
- splenitis, splenomegaly in late syphilis (A52.79)
- splenitis, splenomegaly in tuberculosis (A18.85)
- splenomegaly NOS (R16.1)
- splenomegaly congenital (Q89.0)
- Excludes1: neutropenic splenomegaly (D73.81)
- D73.2 Chronic congestive splenomegaly
- D73.3 Abscess of spleen
- D73.4 Cyst of spleen
- D73.5 Infarction of spleen
- Splenic rupture, nontraumatic
- Torsion of spleen
- Excludes1: rupture of spleen due to Plasmodium vivax malaria (B51.0)
- traumatic rupture of spleen (S36.03-)
- D73.8 Other diseases of spleen
- D73.81 Neutropenic splenomegaly
- Werner-Schultz disease
- D73.89 Other diseases of spleen
- Fibrosis of spleen NOS
- Perisplenitis
- Splenitis NOS
- D73.81 Neutropenic splenomegaly
- D73.9 Disease of spleen, unspecified
D74 Methemoglobinemia
edit- D74.0 Congenital methemoglobinemia
- Congenital NADH-methemoglobin reductase deficiency
- Hemoglobin-M [Hb-M] disease
- Methemoglobinemia, hereditary
- D74.8 Other methemoglobinemias
- Acquired methemoglobinemia (with sulfhemoglobinemia)
- Toxic methemoglobinemia
- D74.9 Methemoglobinemia, unspecified
D75 Other and unspecified diseases of blood and blood-forming organs
edit- Excludes2: acute lymphadenitis (L04.-)
- chronic lymphadenitis (I88.1)
- enlarged lymph nodes (R59.-)
- hypergammaglobulinemia NOS (D89.2)
- lymphadenitis NOS (I88.9)
- mesenteric lymphadenitis (acute) (chronic) (I88.0)
- D75.0 Familial erythrocytosis
- Benign polycythemia
- Familial polycythemia
- Excludes1: hereditary ovalocytosis (D58.1)
- D75.1 Secondary polycythemia
- Acquired polycythemia
- Emotional polycythemia
- Erythrocytosis NOS
- Hypoxemic polycythemia
- Nephrogenous polycythemia
- Polycythemia due to erythropoietin
- Polycythemia due to fall in plasma volume
- Polycythemia due to high altitude
- Polycythemia due to stress
- Polycythemia NOS
- Relative polycythemia
- Excludes1: polycythemia neonatorum (P61.1)
- polycythemia vera (D45)
- D75.8 Other specified diseases of blood and blood-forming organs
- D75.81 Myelofibrosis
- Myelofibrosis NOS
- Secondary myelofibrosis NOS
- Code first the underlying disorder, such as:
- malignant neoplasm of breast (C50.-)
- Use additional code, if applicable, for associated therapy-related myelodysplastic syndrome (D46.-)
- Use additional external cause code, if due to antineoplastic chemotherapy (T45.1-)
- Excludes1: acute myelofibrosis (C94.4-)
- idiopathic myelofibrosis (D47.1)
- leukoerythroblastic anemia (D61.82)
- myelofibrosis with myeloid metaplasia (D47.4)
- myelophthisic anemia (D61.82)
- myelophthisis (D61.82)
- primary myelofibrosis (D47.1)
- D75.82 Heparin induced thrombocytopenia (HIT)
- D75.89 Other specified diseases of blood and blood-forming organs
- D75.81 Myelofibrosis
- D75.9 Disease of blood and blood-forming organs, unspecified
D76 Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue
edit- Excludes1: (Abt-) Letterer-Siwe disease (C96.0)
- eosinophilic granuloma (C96.6)
- Hand-Schüller-Christian disease (C96.5)
- histiocytic sarcoma (C96.a)
- histiocytosis X, multifocal (C96.5)
- histiocytosis X, unifocal (C96.6)
- malignant histiocytosis (C96.a)
- Langerhans-cell histiocytosis, multifocal (C96.5)
- Langerhans-cell histiocytosis NOS (C96.6)
- Langerhans-cell histiocytosis, unifocal (C96.6)
- leukemic reticuloendotheliosis or reticulosis (C91.4-)
- lipomelanotic reticuloendotheliosis or reticulosis (I89.8)
- Excludes1: (Abt-) Letterer-Siwe disease (C96.0)
- D76.1 Hemophagocytic lymphohistiocytosis
- Familial hemophagocytic reticulosis
- Histiocytoses of mononuclear phagocytes
- D76.2 Hemophagocytic syndrome, infection-associated
- Use additional code to identify infectious agent or disease.
- D76.3 Other histiocytosis syndromes
- Reticulohistiocytoma (giant-cell)
- Sinus histiocytosis with massive lymphadenopathy
- Xanthogranuloma
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
edit- Code first underlying disease, such as:
- amyloidosis (E85.-)
- congenital early syphilis (A50.0)
- echinococcosis (B67.0-B67.9)
- malaria (B50.0-B54)
- schistosomiasis [bilharziasis] (B65.0-B65.9)
- vitamin C deficiency (E54)
- Excludes1: rupture of spleen due to Plasmodium vivax malaria (B51.0)
- splenitis, splenomegaly in:
- late syphilis (A52.79)
- tuberculosis (A18.85)
Intraoperative and postprocedural complications of the spleen (D78)
D78 Intraoperative and postprocedural complications of the spleen
edit- D78.0 Intraoperative hemorrhage and hematoma of spleen complicating a procedure
- Excludes1: intraoperative hemorrhage and hematoma of spleen due to accidental puncture or laceration during a procedure (D78.1-)
- D78.01 Intraoperative hemorrhage and hematoma of spleen complicating a procedure on the spleen
- D78.02 Intraoperative hemorrhage and hematoma of spleen complicating other procedure
- D78.1 Accidental puncture and laceration of spleen during a procedure
- D78.11 Accidental puncture and laceration of spleen during a procedure on the spleen
- D78.12 Accidental puncture and laceration of spleen during other procedure
- D78.2 Postprocedural hemorrhage and hematoma of spleen following a procedure
- D78.21 Postprocedural hemorrhage and hematoma of spleen following a procedure on the spleen
- D78.22 Postprocedural hemorrhage and hematoma of spleen following other procedure
- D78.8 Other intraoperative and postprocedural complications of spleen
- Use additional code, if applicable, to further specify disorder
- D78.81 Other intraoperative complications of spleen
- D78.89 Other postprocedural complications of spleen
Certain disorders involving the immune mechanism (D80-D89)
edit- Includes: defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
- Excludes1: autoimmune disease (systemic) NOS (M35.9)
- functional disorders of polymorphonuclear neutrophils (D71)
- human immunodeficiency virus [HIV] disease (B20)
D80 Immunodeficiency with predominantly antibody defects
edit- D80.0 Hereditary hypogammaglobulinemia
- Autosomal recessive agammaglobulinemia (Swiss type)
- X-linked agammaglobulinemia [Bruton] (with growth hormone deficiency)
- D80.1 Nonfamilial hypogammaglobulinemia
- Agammaglobulinemia with immunoglobulin-bearing B-lymphocytes
- Common variable agammaglobulinemia [CVAgamma]
- Hypogammaglobulinemia NOS
- D80.2 Selective deficiency of immunoglobulin A [IgA]
- D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
- D80.4 Selective deficiency of immunoglobulin M [IgM]
- D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
- D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
- D80.7 Transient hypogammaglobulinemia of infancy
- D80.8 Other immunodeficiencies with predominantly antibody defects
- Kappa light chain deficiency
- D80.9 Immunodeficiency with predominantly antibody defects, unspecified
D81 Combined immunodeficiencies
edit- Excludes1: autosomal recessive agammaglobulinemia (Swiss type) (D80.0)
- D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
- D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
- D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
- D81.3 Adenosine deaminase [ADA] deficiency
- D81.4 Nezelof's syndrome
- D81.5 Purine nucleoside phosphorylase [PNP] deficiency
- D81.6 Major histocompatibility complex class I deficiency
- Bare lymphocyte syndrome
- D81.7 Major histocompatibility complex class II deficiency
- D81.8 Other combined immunodeficiencies
- D81.81 Biotin-dependent carboxylase deficiency
- Multiple carboxylase deficiency
- Excludes1: biotin-dependent carboxylase deficiency due to dietary deficiency of biotin (E53.8)
- D81.810 Biotinidase deficiency
- D81.818 Other biotin-dependent carboxylase deficiency
- Holocarboxylase synthetase deficiency
- Other multiple carboxylase deficiency
- D81.819 Biotin-dependent carboxylase deficiency, unspecified
- Multiple carboxylase deficiency, unspecified
- D81. 89 Other combined immunodeficiencies
- D81.81 Biotin-dependent carboxylase deficiency
- D81.9 Combined immunodeficiency, unspecified
- Severe combined immunodeficiency disorder [SCID] NOS
D82 Immunodeficiency associated with other major defects
edit- Excludes1: ataxia telangiectasia [Louis-Bar] (G11.3)
- D82.0 Wiskott-Aldrich syndrome
- Immunodeficiency with thrombocytopenia and eczema
- D82.1 Di George's syndrome
- Pharyngeal pouch syndrome
- Thymic alymphoplasia
- Thymic aplasia or hypoplasia with immunodeficiency
- D82.2 Immunodeficiency with short-limbed stature
- D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
- X-linked lymphoproliferative disease
- D82.4 Hyperimmunoglobulin E [IgE] syndrome
- D82.8 Immunodeficiency associated with other specified major defects
- D82.9 Immunodeficiency associated with major defect, unspecified
D83 Common variable immunodeficiency
edit- D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
- D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
- D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
- D83.8 Other common variable immunodeficiencies
- D83.9 Common variable immunodeficiency, unspecified
D84 Other immunodeficiencies
edit- D84.0 Lymphocyte function antigen-1 [LFA-1] defect
- D84.1 Defects in the complement system
- C1 esterase inhibitor [C1-INH] deficiency
- D84.8 Other specified immunodeficiencies
- D84.9 Immunodeficiency, unspecified
D86 Sarcoidosis
edit- D86.0 Sarcoidosis of lung
- D86.1 Sarcoidosis of lymph nodes
- D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
- D86.3 Sarcoidosis of skin
- D86.8 Sarcoidosis of other sites
- D86.81 Sarcoid meningitis
- D86.82 Multiple cranial nerve palsies in sarcoidosis
- D86.83 Sarcoid iridocyclitis
- D86. 84 Sarcoid pyelonephritis
- Tubulo-interstitial nephropathy in sarcoidosis
- D86.85 Sarcoid myocarditis
- D86.86 Sarcoid arthropathy
- Polyarthritis in sarcoidosis
- D86.87 Sarcoid myositis
- D86.89 Sarcoidosis of other sites
- Hepatic granuloma
- Uveoparotid fever [Heerfordt]
- D86.9 Sarcoidosis, unspecified
D89 Other disorders involving the immune mechanism, not elsewhere classified
edit- Excludes1: hyperglobulinemia NOS (R77.1)
- monoclonal gammopathy (of undetermined significance) (D47.2)
- Excludes2: transplant failure and rejection (T86.-)
- D89.0 Polyclonal hypergammaglobulinemia
- Benign hypergammaglobulinemic purpura
- Polyclonal gammopathy NOS
- D89.1 Cryoglobulinemia
- Cryoglobulinemic purpura
- Cryoglobulinemic vasculitis
- Essential cryoglobulinemia
- Idiopathic cryoglobulinemia
- Mixed cryoglobulinemia
- Primary cryoglobulinemia
- Secondary cryoglobulinemia
- D89.2 Hypergammaglobulinemia, unspecified
- D89.3 Immune reconstitution syndrome
- Code first (T36-T50) to identify drug, if drug induced
- D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
- D89.81 Graft-versus-host disease
- Code first underlying cause, such as:
- complications of transplanted organs and tissue (T86.-)
- complications of blood transfusion (T80.89)
- Use additional code to identify associated manifestations, such as:
- desquamative dermatitis (L30.8)
- diarrhea (R19.7)
- elevated bilirubin (R17)
- hair loss (L65.9)
- D89.810 Acute graft-versus-host disease
- D89.811 Chronic graft-versus-host disease
- D89.812 Acute on chronic graft-versus-host disease
- D89. 813 Graft-versus-host disease, unspecified
- Code first underlying cause, such as:
- D89.82 Autoimmune lymphoproliferative syndrome [ALPS]
- D89.89 Other specified disorders involving the immune mechanism, not elsewhere classified
- Excludes1: human immunodeficiency virus disease (B20)
- D89.81 Graft-versus-host disease
- D89.9 Disorder involving the immune mechanism, unspecified
- Immune diseaseNOS