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of ascaris lumbricoides may, by reflex action, set up a very painful nervous spasm; and certain forms of influenza (q.v.) are ushered in by colic of a very pronounced type. Many physicians describe a rheumatic colic due to cold and damp, and among women disease of the pelvic organs may give rise to an exactly similar pain. There are also those forms of colic which must be classed as functional or neuralgic, though this view of the case must never be accepted until every other possible cause is found to be untenable. From this short account of a few of the commoner causes of the trouble, it will be clear that colic is merely a symptom of disease, not a disease in itself, and that no diagnosis has been made until the cause of the pain has been determined.

Intestinal colic is paroxysmal, usually both beginning and ending suddenly. The pain is generally referred to the neighbourhood of the umbilicus, and may radiate all over the abdomen. It varies in intensity from a slight momentary discomfort to a pain so severe as to cause the patient to shriek or even to break out into a cold clammy sweat. It is usually relieved by pressure, and this point is one which aids in the differential diagnosis between a simple colic and peritonitis, the pain of the latter being increased by pressure. But should the colic be due to a malignant growth, or should the intestines be distended with gas, pressure will probably increase the pain. The temperature is usually subnormal, but may be slightly raised, and the pulse is in proportion.

In the treatment of simple colic the patient must be confined to bed, hot fomentations applied to the abdomen and a purge administered, a few drops of laudanum being added when the pain is exceptionally severe. But the whole difficulty lies in making the differential diagnosis. Acute intestinal obstruction (ileus) begins just as an attack of simple colic, but the rapid increase of illness, frequent vomiting, anxious countenance, and still more the condition of the pulse, warn a trained observer of the far more serious state. Appendicitis and peritonitis, as also the gastric crises of locomotor ataxy, must all be excluded.

COLIGNY, GASPARD DE (1519–1572), admiral of France and Protestant leader, came of a noble family of Burgundy, who traced their descent from the 11th century, and in the reign of Louis XI. were in the service of the king of France. His father, Gaspard de Coligny, known as the maréchal de Châtillon (d. 1522), served in the Italian wars from 1495 to 1515, and was created marshal of France in 1516. By his wife, Louise de Montmorency, sister of the future constable, he had three sons: Odet, cardinal de Châtillon; Gaspard, the admiral; and Francis, seigneur d’Andelot; all of whom played an important part in the first period of the wars of religion. At twenty-two young Gaspard came to court, and there contracted a friendship with Francis of Guise. In the campaign of 1543 Coligny distinguished himself greatly, and was wounded at the sieges of Montmédy and Bains. In 1544 he served in the Italian campaign under the duke of Enghien, and was knighted on the field of Ceresole. Returning to France, he took part in different military operations; and having been made colonel-general of the infantry (April 1547), exhibited great capacity and intelligence as a military reformer. He was made admiral on the death of d’Annebaut (1552). In 1557 he was entrusted with the defence of Saint Quentin. In the siege he displayed great courage, resolution, and strength of character; but the place was taken, and he was imprisoned in the stronghold of L’Ecluse. On payment of a ransom of 50,000 crowns he recovered his liberty. But he had by this time become a Huguenot, through the influence of his brother, d’Andelot—the first letter which Calvin addressed to him is dated the 4th of September 1558—and he busied himself secretly with protecting his co-religionists, a colony of whom he sent to Brazil, whence they were afterwards expelled by the Portuguese.

On the death of Henry II. he placed himself, with Louis, prince of Condé, in the front of his sect, and demanded religious toleration and certain other reforms. In 1560, at the Assembly of Notables at Fontainebleau, the hostility between Coligny and Francis of Guise broke forth violently. When the civil wars began in 1562, Coligny decided to take arms only after long hesitation, and he was always ready to negotiate. In none of these wars did he show superior genius, but he acted throughout with great prudence and extraordinary tenacity; he was “le héros de la mauvaise fortune.” In 1569 the defeat and death of the prince of Condé at Jarnac left him sole leader of the Protestant armies. Victorious at Arnay-le-Duc, he obtained in 1570 the pacification of St Germain. Returning to the court in 1571, he grew rapidly in favour with Charles XI. As a means of emancipating the king from the tutelage of his mother and the faction of the Guises, the admiral proposed to him a descent on Spanish Flanders, with an army drawn from both sects and commanded by Charles in person. The king’s regard for the admiral, and the bold front of the Huguenots, alarmed the queen-mother; and the massacre of St Bartholomew was the consequence. On the 22nd of August 1572 Coligny was shot in the street by Maurevel, a bravo in the pay of the queen-mother and Guise; the bullets, however, only tore a finger from his right hand and shattered his left elbow. The king visited him, but the queen-mother prevented all private intercourse between them. On the 24th of August, the night of the massacre, he was attacked in his house, and a servant of the duke of Guise, generally known as Besme, slew him and cast him from a window into the courtyard at his master’s feet. His papers were seized and burned by the queen-mother; among them, according to Brantôme, was a history of the civil war, “très-beau et tres-bien faict, et digne d’estre imprimé.”

By his wife, Charlotte de Laval, Coligny had several children, among them being Louise, who married first Charles de Téligny and afterwards William the Silent, prince of Orange, and Francis, admiral of Guienne, who was one of the devoted servants of Henry IV. Gaspard de Coligny (1584–1646), son of Francis, was marshal of France during the reign of Louis XIII.

See Jean du Bouchet, Preuves de l’histoire généalogique de l’illustre maison de Coligny (Paris, 1661); biography by François Hotman, 1575 (French translation, 1665); L. J. Delaborde, Gaspard de Coligny (1879–1882); Erich Marcks, Gaspard von Coligny, sein Leben und das Frankreich seiner Zeit (Stuttgart, 1892); H. Patry, “Coligny et la Papauté,” in the Bulletin du protestantisme français (1902); A. W. Whitehead, Gaspard de Coligny, Admiral of France (1904); and C. Merki, L’Amiral de Coligny (1909).

COLIMA, a small Pacific coast state of Mexico, lying between Jalisco on the N.W. and N., and Michoacan on the E. Including the Revilla Gigédo islands its area is only 2272 sq. m., which thus makes it the second smallest of the Mexican states. Pop. (1895) 55,264; (1900) 65,115. The larger part of its territory is within the narrow, flat coastal plain, beyond which it rises toward the north-east into the foothills of the Sierra Madre, the higher masses of the range, including the Colima volcano, lying outside the state. It is drained by the Ameria and Coahuayana rivers and their affluents, which are largely used for irrigation. There are tidewater lagoons and morasses on the coast which accentuate its malarious character. One of the largest of these, Cuitlán, immediately south of Manzanillo, is the centre of a large salt-producing industry. The soil is generally fertile and productive, but lack of transportation facilities has been a serious obstacle to any production greatly exceeding local demands. The dry and rainy seasons are sharply defined, the rainfall being abundant in the latter. The climate is hot, humid and malarious, becoming drier and healthier on the higher mountain slopes of the interior. Stock-raising is an important industry in the higher parts of the state, but the horses, mules and cattle raised have been limited to local demands. Agriculture, however, is the principal occupation of the state, the more important products being sugar, rice, Indian corn, palm oil, coffee, indigo, cotton and cacao. The production of cacao is small, and that of indigo and cotton is declining, the latter being limited to the requirements of small local mills. There are two crops of Indian corn a year, but sugar and rice are the principal crops. The “Caracolillo” coffee, produced on the slopes of the mountains culminating in the volcano of Colima, is reputed the best in Mexico, and the entire crop (about 506,000 ℔. in 1906) is consumed in the country at a price much above other grades. There are important mineral deposits in the