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( 4 ) be fald of every medicine ; and though Dr. Cullen repeatedly ex- perienced its inefficacy, yet the fadts he adduces in confirmation of the utility of this plant, are clear and decifive : “ I have had a cancer “ of the lip entirely cured by it ; a feirrhofity in a woman’s breaft, “ of fuch a kind as frequently proceeds to cancer, I have found “ entirely difeufl'ed by the ufe of it ; a fore a little below the eye, “ which had put on a cancerous appearance, was much mended by “ the internal ufe of the Belladonna : but the patient having learned “ fomewhat of the poifonous nature of the medicine, refufed to “ continue the ufe of it, upon which the fore again fpread, and “ was painful ; but upon a return to the ufe of the Belladonna, was “ again mended to a confiderable degree : when the fame fears again “ returning, the ufe of it was again laid afide, and with the fame “ confequence of the fore becoming worfe. Of thefe alternate “ ftates, conned:ed with the alternate ufe of, and abftinence from, “ the Belladonna, there were feveral of thefe alternations which fell “ under my own obfervation.” The fenfible effects produced by the leaves of this plant taken in medicinal dofes, are ufually by the fkin, the urinary paflages, and fometimes by ftool ; in larger dofes troublefome drynefs of the mouth and throat, giddinefs, and dimnefs of fight are experienced. That the advantages derived from the internal ufe of Belladonna are only in proportion to the evacuations effedfed by it, is a con- clufion we cannot admit as fufficiently warranted by the fadts adduced upon this point. As this plant is very uncertain in its operation, the proper dofe is with difficulty afeertained ; the moft prudent manner of adminifier- ing it is by beginning with one grain or lefs, which may be gradually increafed according to its effedts. Six grains are confidered as a very large dofe. — With refpedl to the berries, fo fuccefsfully employed as an anodyne, by Gefner and others, in dyfenteries, a fmall fpoonful (coch. parvum) of a fyrup of the juice was the dofe given. The root feems to partake of the fame qualities as the leaves, but is lefs virulent. MENYANTHES TRIFOLIATA.